STUDIES ON FREE AMINO ACIDS IN HUMAN BRAIN
1960 年 47 巻 3 号 p. 315-320
詳細
1960 年 47 巻 3 号 p. 315-320
1. The analysis of amino acids in the protein-free extracts of the human brain has been carried out by means of ion exchange chromatography.
2. The various areas of brains were obtained from the individual dying of accident and from fetuses on the fifth and eighth gravid months. Four fresh brain tissues were obtained during the surgical operation in the patients with cerebral tumors or with epilepsy.
3. In general the distribution pattern of the free amino acids in the various areas of the human brains resembled that in dog. γ-Aminobutyric acid was detected in a large amount in the globus pallidus and the hypothalamus.
4. The quantities of free amino acids in the fetal brains differ significantly from those in the mature human brain. Taurine and phosphoethanolamine were detected in a larger amount and glutamic acid, aspartic acid, γ-amino-butyric acid and N-acetylaspartic acid were less.
5. In the brains from brain tumors there was a considerable amount of cystathionine. In the brains of accidental death and of epilepsy this substance was far less. In the fetal brains this could hardly be recognized.
