Abstract
Japanese agar was one of the most available and suitable substance which might produce a granuloma when it was implanted subcutaneously in a rat.
The characteristics of the granuloma-producing substances and also some problems in the collagen biosynthesis were discussed.
The authors express their many thanks to Prof. N. Shimazono of the Dept. of Biochemistry, Faculty of Medicine, Universtiy of Tokyo, for his guidance and encouragement during the work.
