The Metabolic Fate of Hexose-6-O-[S³⁵]-Sulphates and Related Compounds

抄録

The injection of D-glucose-6-O-[S³⁵]-sulphate and D-galactose-6-O-[S³⁵]-sulphate in rats is characterised by the excretion of the larger part of the injected dose in the urine in an unchanged form accompanied by limited amounts of inorganic [S³⁵] sulphate. Urinary excretion of ester [S³⁵] sulphate and inorganic [S³⁵] sulphate is also a characteristic of ex-periments in which a [S³⁵] sulphatide is injected in rats, although in these instances a substantial portion of radioactivity is also excreted via the bile.
Evidence is presented that D-galactose is unlikely to function as an acceptor for sulphate in the biosynthesis of naturally-occurring com-pounds containing D-galactose sulphate residues.
This work has been supported by grants to A. G. L. from the Empire Rheumatism Council and the Nuffield Foundation and a grant (A1982) from the Arthritis and Metabolic Diseases Division of the U. S. Public Health Service. P. J. L. and A. M. J. are grateful to the Medical Research Council for a Research Fel-lowship and a Research Studentship respectively. The authors wish to express their thanks to Dr. H. Jatzkewitz and Dr. J. H. Austin for samples of sulphatide preparations. Finally, Professor Dodgson wishes to acknowledge the work of Professor T. Soda which first stimulated the interest of the Cardiff Laboratories in carbohydrate sulphates.