Abstract
Rats were fed diets containing cholesterol and coconut oil or linoleic acid. The con-centration of lipids was determined in serum as well as in ultracentrifugal fractions of the liver.
Feeding with high fat alone produced some minor fatty infiltration in the liver, but in cholesterol-fed rats the administration of high fat accentuated the lipid deposition. The major location of the exogenous lipid deposited in the liver was associated first with a centripetally migrating fraction.
The elevation of serum cholesterol level was observed only in the cholesterol plus linoleate-fed rat.
There was a slight increase in cell particulate phospholipid level in the liver of the linoleate-fed.
The authors wish to express their deep gratitude to Professor Emeritus M. Yasuda under whose direction an early part of the work was carried out.
