Studies on the Mechanism of Action of the Adrenocorticotropic Hormone in Fat Mobilization
1967 年 62 巻 5 号 p. 599-603
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1967 年 62 巻 5 号 p. 599-603
Calcium ion is required for ACTH to exert a lipolytic action on ratepididymal adipose tissue slices.Other metal ions such as Mg++, Zn++, Cu++, Ba++ and Mn++ can not substitute for Ca++.In the adipose tissue homogenate the action of ACTH disappears and calcium ion stimulates lipolysis.Besides, ACTH increases the incorporation of calcium ion into the adipose tissue slices.All these results suggest that the lipolytic effect of ACTH might be mediated through calcium ion.
