Hormonal Regulaton of Aminopyrine N-Demethylase System in Rat Liver
1969 Volume 65 Issue 4 Pages 597-601
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1969 Volume 65 Issue 4 Pages 597-601
1. Role of the hormones of adrenal and testis in regulating hepatic microsomal aminopyrine N-demethylase activity was studied in male rats that were subjected to adrenalectomy, castration or both with or without replacement therapy.
2. Corticoid and androgen were found to regulate different fractions of the amino-pyrine N-demethylase activity, and level of this enzyme activity was shown to be mainly maintained by corticoid and androgen in intact male rats. Size and rate of decrease of the corticoid- and androgen-dependent fractions were almost the same to each other.
3. Phenobarbiturate-inducible fraction of the aminopyrine N-demethylase activity was quite independent of the adrenal and testicular control.
4. NADPH-cytochrome c reductase, NADH-cytochrome c reductase, and cytochromes P-450 and b5 of microsomal fraction were determined in livers of the operated rats.
