Association of Human α1-Antitrypsin with Anhydrotrypsin
1975 年 78 巻 5 号 p. 925-928
詳細
1975 年 78 巻 5 号 p. 925-928
Unlike in the reaction of anhydrotrypsin and soybean trypsin inhibitor, human α1-antitrypsin was found not to form a complex with bovine anhydrotrypsin. This was shown using three different methods: electrophoresis, affinity chromatography on an anhydrotrypsin-coupled Sepharose column and equilibrium competitive binding assay.These results indicate the importance of the active site serine of trypsin in formation of a complex with α1-antitrypsin.
