Occurrence of Tetrodotoxin and Anhydrotetrodotoxin in Vibrio sp. Isolated from the Intestines of a Xanthid Crab, Atergatis floridus

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Vibrio sp. isolated from a xanthid crab, Atergatis floridus, was cultured, and tetrodotoxin (TTX) and anhydro TTX were indicated to be present in several fractions of the cell extract and the culture medium by reverse phase HPLC. The presence of the C₉-base in alkaline hydrolyzates of these fractions was confirmed by GC-MS and UV spectrometry. These results showed the production of TTX and anhydro-TTX in the Vibrio sp., thus indicating one of the origins of TTX in nature.