Abstract
The purpose of thisreview is to clarify the rapid self setting reaction of apatite cement (SSAC) consisting
of tetracalcium phosphate (TeCP) and dicalcium phosphate dihydrate (DCPD) by ombining attenuated
total reflection Fourier transform infrared spectroscopy (ATR IR) and m ultivariate analysis . The ATR IR
spectra of the sample showed characteristic phosphoric acid peak due to crystalline transformation from
TeCP and DCPD into hydroxyapatite (HAp). M ultivariate analysis result s indicated that HA p wa s formed
by precipitation and re dissolution of T e CP and DCPD in the samples. In the case of HAp crystallization
with amino acids , serine and phospho serine were adsorbed onto HAp seed crystals and inhibit their
crystallization was indicated. It is concluded that the It is concluded that the electrostatic interaction
between seed HAp crystal and amino acids has to be considered for developing drug delivery system.
