Evaluation of phase transition in bio ceramic synthesis; attenuated total reflection infrared spectra and multivariate analysis for calcium phosphate

Abstract

The purpose of thisreview is to clarify the rapid self setting reaction of apatite cement (SSAC) consisting of tetracalcium phosphate (TeCP) and dicalcium phosphate dihydrate (DCPD) by ombining attenuated total reflection Fourier transform infrared spectroscopy (ATR IR) and m ultivariate analysis . The ATR IR spectra of the sample showed characteristic phosphoric acid peak due to crystalline transformation from TeCP and DCPD into hydroxyapatite (HAp). M ultivariate analysis result s indicated that HA p wa s formed by precipitation and re dissolution of T e CP and DCPD in the samples. In the case of HAp crystallization with amino acids , serine and phospho serine were adsorbed onto HAp seed crystals and inhibit their crystallization was indicated. It is concluded that the It is concluded that the electrostatic interaction between seed HAp crystal and amino acids has to be considered for developing drug delivery system.