Tooth Regenerative Medicine and a Next-generation Implant as Future Novel Dental Treatment.

Abstract

Regenerative medicine is expected as a new medical system for the 21st century. The major goal of dental care in the future is tooth regeneration treatment to regain lost teeth by regeneration. Previously, we developed an Organ Germ Method, a three-dimensional cell manipulation technology, and made it possible to regenerate fully functional teeth such as the periodontal ligament and neural functions by orthotopic transplantation of regenerated a bioengineered tooth germ. As a restoration of teeth that will restore full function as a dental treatment of the future, it is possible not only to transplant regenerated bioengineered tooth germ, but also to regenerate functional teeth that do not become dental caries by imparting the periodontal ligament to the current osseo-integrate implant treatment. As a next-generation implant treatment, we have developed a biohybrid implant that has periodontal tissue and expresses the physiological functions of teeth. In addition, we are developing implant material and examining non-clinical efficacy using large animals. In this paper, we introduce the strategy and progress of research for the realization of dental regenerative medicine as a dental treatment in the future.