Abstract
Based on the remarkable progress of researches in the fields of tissue engineering and regenerative medicine, the possibility of cell therapy using cultured cells for various diseases and dysfunctional tissues has been widely suggested. In the field of dentistry, many studies have been conducted, aiming to develop new cell-based therapies for various diseases such as regeneration of oral tissues, periodontal diseases, pulpitis, mucosal diseases, and salivary gland diseases. We have examined the possibility of periodontal tissue regeneration by cell transplantation and demonstrated the utility of cell sheet technology for the regeneration of periodontal tissues as a simple and reliable method of cell transplantation. Furthermore, periodontal tissue regeneration on the surface of titanium implants was also verified using this technique. In this review, we outline cell sheet technology and its potential for construction of implants with periodontal tissues.
