Journal of Bio-Integration
Online ISSN : 2186-2923
Preparation of fluoridated hydroxyapatite thin films by laser deposition technique and in vitro evaluation of its biocompatibility
Shigeki HontsuHiroaki NishikawaMasanobu KusunokiYoshiya Hashimoto
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JOURNAL OPEN ACCESS

2013 Volume 3 Issue 1 Pages 67-70

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Abstract
Fluoridated hydroxyapatite (Ca10(PO4)6(OH)2-2xF2x; FHAp) is expected to be much more effective than hydroxyapatite (HAp) in medical and dental applications due to its good acid-resistance. In this paper, we report the results of fabrication of FHAp films and in vitro evaluation of its biocompatibility. FHAp films were deposited on Ti substrates by PLD using an ArF excimer laser. XRD results showed that the length of the a-axis of FHAp film decreased compared to the standard length of HAp. In the FT-IR analysis, it was confirmed that part of OH- was replaced by F-. From the FT-IR analysis, the FHAp film yielded a fluorine signal. In the in-vitro cell test, it was proven that FHAp film showed excellent cell proliferation of the degree equal to HAp film. These results indicate that we succeeded in the fabrication of FHAp film that is very useful as the implant coating material in the next generation.
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© 2013 Bio Integration Society
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