Abstract
Magnesium substituted hydroxyapatite (Mg-HA) thin films were prepared using an rf-magnetron sputtering
method. The Mg-HA films were coated onto titanium (Ti) substrates from mixed HA/MgO powder targets. The
ratio of Mg / (Mg + Ca) of the target was varied in the ratio of 5, 10, 20, 40, 60 and 80%. The coated films were
crystallized by a hydrothermal treatment to reduce the dissolution rate of the films. In the determination of the
chemical compositions of the Mg-HA films before and after the hydrothermal treatment, the films were dissolved
in an acid solution, and the solutions were measured by inductively coupled plasma mass spectrometry (ICP-MS).
The bone formation of the films was evaluated by the bone formation area of osteoblast cells.
The chemical analysis showed Mg concentration of the films increased with the ratio of Mg / (Mg + Ca) of
the target, but the Mg concentration decreased after the hydrothermal treatment. In the cell culture, the bone
formation area on the Mg-HA films decreased with increasing Mg concentration of the films.
