Biomedical Research
Online ISSN : 1880-313X
Print ISSN : 0388-6107
ISSN-L : 0388-6107
Full Papers
Circadian characteristics of mice depleted with GPR7
Naohiro UchioMasao DoiMasahiro MatsuoFumiyoshi YamazakiYasutaka MizoroMari HondoTakeshi SakuraiHitoshi Okamura
Author information
JOURNALS FREE ACCESS

2009 Volume 30 Issue 6 Pages 357-364

Details
Abstract

GPR7, now known as a receptor of neuropeptide B and neuropeptide W, is expressed in neurons of the suprachiasmatic nucleus (SCN), the mammalian circadian center. By the quantitative in situ hybridization, we demonstrated that GPR7 mRNA showed a significant circadian rhythm in the SCN showing a peak at early subjective night in both light-dark and constant dark. We characterized the circadian feature of GPR7-knockout mice, but the period length and the phase-dependent phase shift to light exposure were not disordered in GPR7-knockout mice. Moreover, the food-anticipatory behavior in restricted feeding schedule was observed in this gene-deleted mouse similar to wild-type. These results indicate that the role of GPR7 may be subtle or limited in relation to the circadian clock despite its robust expression in the SCN.

Information related to the author
© 2009 Biomedical Research Press
Previous article Next article
feedback
Top