1985 Volume 6 Issue 2 Pages 87-91
Procainamide (PA), an anti-arrhythmic agent, was recently found to be a specific inhibitor of suppressor T cells. The effects of PA and X-ray irradiation were studied on both plaque forming cells (PFC) and antibody titer using sheep red blood cells and vaccinia virus as antigens. A single injection of PA (50μg) augmented both PFC and antibody titer; the increase was more than twice that seen after X-ray irradiation. A single injection of higher doses and repeated PA injections did not further augment antibody production. These data indicate that PA could be introduced as the sensitizing step in some experimental antibody-dependent anticancer regimens.
