1987 年 8 巻 5 号 p. 345-348
Cross-reactivity of six novel somatostatin (SRIF) analogs has been examined by SRIF-specific radioimmunoassays using anti-SRIF sera OAL-272 or OAL-283. The analogs examined possessed different chain length in which the S-S linkage was replaced by a methylene bridge of α-amino suberic acid (D-Asu). In the assay using antiserum OAL-272, the labeled SRIF failed to displace any of the six analogs, whereas in the assay with antiserum OAL-283, five of the analogs with the exception of the shortest analog (Phe-D-Trp-Lys-Thr-D-Asu) were bound very weakly (0.01-0.06% vs. SRIF). The results indicate that antisera specific to each of the analogs will be required for assays of these analogs in biological fluids.
