1988 年 9 巻 1 号 p. 81-85
The effect of mazindol on insulin and glucagon secretion was studied in ventromedial hypothalamic (VMH)-lesioned obese rats with hyperinsulinemia. Three weeks after a VMH or sham operation, the rats were divided into two groups: one was fed a balanced diet containing mazindol (50 mg/kg) and the other was fed a balanced diet without mazindol for 3 weeks. In the VMH rats, mazindol treatment was associated with a significant reduction in body weight and calorie intake, but it had no effect in the sham-operated rats. Furthermore, the fasting plasma insulin level and the arginine-induced insulin secretion from the perfused pancreas of VMH rats treated with mazindol were significantly lower than those in VMH rats without mazindol treatment. In addition, mazindol produced no significant change in the insulin secretion of sham-operated rats either in vivo or in vitro. It is therefore suggested that mazindol suppresses the hypersecretion of insulin in VMH rats through an anorectic effect and/or suppression of vagal hyperactivity.
