Recent Progress in the Experimental Studies of Protein Folding Dynamics

Abstract

The experimental studies of protein folding dynamics have made remarkable advances lately. This is attributed to the development of new experimental methods that enable to detect submillisecond dynamics of protein folding as well as to the characterization of folding transition states of small single domain proteins. The characterization of folding intermediates, the elucidation of the processes involved before the formation of folding nucleus and the experimental confirmation of the energy landscape theory are several of important problems that are currently discussed.