A New Stable-Isotope-Aided NMR Method for Structural Determinations of Proteins : The SAIL Method

Abstract

In the post-genomic era the NMR method for structural determinations of proteins has to be high-throughput, accurate, and applicable to larger proteins. Conventional NMR methods, however, do not meet these requirements simultaneously. The stereo-array-isotope-labeling (SAIL) method, which we are currently developing, is an entirely new NMR technique which satisfies all of these criteria.