Seibutsu Butsuri
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
Review
Functions of Nonmuscle Myosin II Isoforms
Masayuki TAKAHASHI, Takashi NAKASAWA, Masaaki SATO, Naoya HIRATA, Mariko MITSUHASHI, Michio YAZAWA
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Keywords: myosin II, nonmuscle cells, filament, phosphorylation, cell migration, subcellular localization
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2006 Volume 46 Issue 1 Pages 15-19

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Abstract
All vertebrate cells, including muscle cells, contain nonmuscle myosin II which plays a role in a number of cell motility processes. Dynamic filament assembly-disassembly transition of myosin II molecules is particularly important in nonmuscle cells. In this review, we describe our recently proposed molecular mechanism for the filament formation of nonmuscle myosin II. We also discuss the distinct functions of two myosin II isoforms, IIA and IIB, during cell migration.
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© 2006 by THE BIOPHYSICAL SOCIETY OF JAPAN
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