Seibutsu Butsuri
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
Review
Traffic Flow and Translation Process
Namiko MITARAI
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JOURNAL FREE ACCESS

2013 Volume 53 Issue 1 Pages 015-019

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Abstract
Messenger RNAs (mRNA), that code sequences of amino acids by using triplets of nucleotides (codons), are translated by multiple ribosomes. Usually more than one codon corresponds to an amino acid. The ribosome speed is known to dependent on the codon, thus there is a room to keep an amino acid sequence (protein) and change the ribosome speed. We model the ribosome traffic with codon-dependent rate estimated for E. coli and show that some wild type codon sequences can regulate “traffic jam” by placing slow codons at the begging of the mRNA. We discuss possible roles of slow codons in translation process.
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© 2013 by THE BIOPHYSICAL SOCIETY OF JAPAN
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