Structural and Functional Characteristics of Protein Phosphorylation Revealed by Bioinformatic Approaches

Abstract

Protein phosphorylation plays a key role in numerous biological processes. Although several well-known phosphoproteins give us deep insights into the detailed properties of protein phosphorylation, comprehensive analyses are still required to understand general features of phosphorylation. Here we describe the structural and functional characteristics of phosphorylation events identified by our database analyses, specifically phosphorylation sites on protein complexes and disorder regions, and activation and inhibition of proteins by multisite phosphorylation.