Spatiotemporal Regulation of T Cell Activation

Abstract

When T cells recognize their cognate antigens with MHCs on antigen-presenting cells, TCRs are gathering to form a signalosome, so-called a TCR microcluster, which is constructed by kinases and adaptors in their downstream. The other receptors expressing on T cells, such as a set of costimulatory receptors, also form microclusters and possess their own characteristic signals. Various signalosomes on a plasma membrane all together regulate T cell activation in a spatiotemporal fashion.