Seibutsu Butsuri
Online ISSN : 1347-4219
Print ISSN : 0582-4052
ISSN-L : 0582-4052
Overview
The Mechanism for the Stomach Acidification
Kazuhiro ABE
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Keywords: membrane transport protein, P-type ATPase, X-ray crystallography, bioenergetics, proton transport, structural biology
JOURNAL FREE ACCESS

2019 Volume 59 Issue 2 Pages 073-078

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Abstract

When we have food intake, pH of the stomach reaches around 1. This highly acidic environment is indispensable for the digestion. Gastric proton pump, H+,K+-ATPase is a membrane protein responsible for the gastric acid secretion. Its crystal structures now reveal how this proton pump extrudes H+ even into the pH 1 environment of the stomach.

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© 2019 by THE BIOPHYSICAL SOCIETY OF JAPAN
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