Structure of Serum Low Density Lipoprotein

Abstract

A brief survey of recent advances in physical and biochemical studies on the structure of low density lipoprotein is made with approximately 20 literatures of immediate interest to the author. The distribution of lipids and proteins in the lipoprotein particle is discussed as a major concern at the present stage of investigation which is still very infantile despite the continued effort of many researchers around the world. The presence of the protein rich shell over the hydrocarbon rich core in the lipoprotein particle has been convincingly proposed by several workers including the present author. The conformation of apo-LDL and the distribution of different lipids in the lipoprotein particle are two of several major problems in this field that await vigorous investigations.