Abstract
The major concern to investigate how to control the malaria disease is to identify effective antigenic genes for the development of vaccine. Several reserch groups have been reporting isolation and characterization of genes for the antigens in some stages of parasite development. Whereas, there is few concrete evidence for the protective ability of the antigens thus far reported. Recent advancement of the reserch suggested the existence of defence mechanism in malaria parasite against the immune system of human. We might have to solve this problem to get an effective vaccille. Here, I briefly reviewed the recent works in this field and also reported the construction of cDNA explession bank and analysis of the gene for the protective antigen p.126. This work was done with Drs. Joseph Inselburg and David Bzik in Dartmouth Medical School.
