1993 Volume 33 Issue 1 Pages 31-36
Structural information about an unfolded state is important for the better understanding of both protein folding and protein itself. Compactness and chain statistics which are essential to characterize an unfolded state are derived by X-ray solution scattering method. In this article, the author describes the examples of studies on a protein unfolded state, such as urea denaturation of Staphylococcal nuclease, acid-denatured and molten globule states of cytochrome c, and a Staphylococcal nuclease fragment which is an unfolded state under a physiological condition. These examples suggest diversity of protein unfolded state.
