Abstract
Computer simulations of metabolic pathways should use a realistic models concerning parameters of enzyme kinetics, and cell dimensions. The enzyme parameters are well determined with a best fit method. And it had better that the models for the analyses of enzyme kinetics is selected on the basis of AIC. Computer simulation of metabolic pathways is a convenient tool for the elucidation of control coefficients. The control coefficient is more quantitative concept to represent a flux control than limiting step is.
