Abstract
Amoeboid movement consists of several fundamental molecular processes in the cortical ectoplasm, such as pseudopod formation and tail retraction. Such processes occur in a local and coordinated manner in one amoeba. We show here that the microtubule system, which is localized in the endoplasm, is the structural basis for the coordination of the cell cortex. The microtubule system functions so that the individual processes can be related spatially and temporally with each other in several different ways, thus enabling a cell to walk randomly. Chemoattractants serve as information to yield one specific spitial arrangement suitable for migration toward the source.
