1998 Volume 38 Issue 3 Pages 111-115
Essential ideas in the protein 3D-1D compatibility analysis are briefly introduced. The 3D-1D alignment was revolutionary in the establishment of the methodology. The method is applicable for structure prediction, stability evaluation of point mutants, deducing functional sites etc. In these applications it appears free of the protein folding problem, however, this is not the case if we try to design de-novo sequence.