Biophysics and Physicobiology
Review Article
Operating principles of rotary molecular motors: differences between F1 and V1 motors
Ichiro YamatoYoshimi KakinumaTakeshi Murata
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Volume 13 (2016) Pages 37-44

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Abstract

Among the many types of bioenergy-transducing machineries, F- and V-ATPases are unique bio- and nano-molecular rotary motors. The rotational catalysis of F1-ATPase has been investigated in detail, and molecular mechanisms have been proposed based on the crystal structures of the complex and on extensive single-molecule rotational observations. Recently, we obtained crystal structures of bacterial V1-ATPase (A3B3 and A3B3DF complexes) in the presence and absence of nucleotides. Based on these new structures, we present a novel model for the rotational catalysis mechanism of V1-ATPase, which is different from that of F1-ATPases.

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© 2016 THE BIOPHYSICAL SOCIETY OF JAPAN
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