BIOPHYSICS
Online ISSN : 1349-2942
ISSN-L : 1349-2942
Review Article
Revealing the peptide presenting process of human leukocyte antigen through the analysis of fluctuation
Saeko YanakaTakamasa UenoKouhei TsumotoKenji Sugase
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ジャーナル フリー

2015 年 11 巻 p. 103-106

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Structural fluctuation on microsecond to millisecond time scales has been reported to play an important role in proteins that undergo significant structural change during their expression of function. In these proteins, the structural change was obvious in the crystal structures. However, protein motions in solution could contribute to the function of proteins, even if no significant structural difference is observed in crystal structure of different states while they function. In this review, we introduce our recent report on the stabilization mechanism of human leukocyte antigen, and the possibility of fluctuation contributing to several biophysical properties of proteins.

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© 2015 THE BIOPHYSICAL SOCIETY OF JAPAN
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