Inhibition of Lipid Droplet Accumulation in Macrophages by Triterpenoids Produced from Torametes orientaris

Taichi Ohshiro; Ichiji Namatame; Kana Ochiai; Hirokazu Kawagishi; Hiroshi Tomoda

doi:10.1248/bpb.28.1925

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Inhibition of Lipid Droplet Accumulation in Macrophages by Triterpenoids Produced from Torametes orientaris

Taichi Ohshiro, Ichiji Namatame, Kana Ochiai, Hirokazu Kawagishi, Hiroshi Tomoda

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Keywords: lipid droplet accumulation, triterpenoid inhibitor, atherosclerosis, macrophage, neutral lipid synthesis, Torametes orientaris

JOURNAL FREE ACCESS

2005 Volume 28 Issue 10 Pages 1925-1927

DOI https://doi.org/10.1248/bpb.28.1925

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Abstract

Four triterpenoids 1—4 isolated from the fruit body of Torametes orientaris were found to inhibit lipid droplet accumulation in macrophages. From the biochemical analysis, compounds 2 and 3 inhibited selectively cholesteryl ester synthesis in macrophages, while compounds 1 and 4 showed inhibition of both cholesteryl ester and triacylglycerol syntheses.

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