Type 2 diabetes mellitus (T2DM) animal models are often used in basic research on diabetic osteoporosis. The article by Tanaka et al. elucidated hyperglycemia contributed to a decrease in bone metabolism turnover in the T2DM animal model NSY mice, resulting in a thinner and shorter femur, lower cortical and trabecular area, and lower bone mass. Their results suggest that these effects contribute to the deteriorated bone strength of the femur in NSY mice, and the NSY mouse could serve as an appropriate T2DM animal model for examining the specific effect of hyperglycemia on bone integrity, using the ICR mouse as a control.
Total Purine and Purine Base Content of Common Foodstuffs for Facilitating Nutritional Therapy for Gout and Hyperuricemia
Released: May 01, 2014 | Volume 37 Issue 5 Pages 709-721
Kiyoko Kaneko, Yasuo Aoyagi, Tomoko Fukuuchi, Katsunori Inazawa, Noriko Yamaoka