Based on the binding characteristics, Kamei et al. attempted to increase the bound concentration of penetratin, cell-penetrating peptide (CPP), by increasing the concentration of mixed insulin, however the effect of L-penetratin on the oral absorption of insulin was not boosted by increasing the dose of insulin. The investigation in the gastric pH-neutralized mice showed that the dissociation of noncovalent complexes of insulin and CPPs at the low gastric pH was prevented in these mice, and clearly suggested that a noncovalent theoretical strategy with CPPs represents an effective approach for the L-form of CPP to attain greater absorption of insulin.
Total Purine and Purine Base Content of Common Foodstuffs for Facilitating Nutritional Therapy for Gout and Hyperuricemia
May 01, 2014 | Volume 37 Issue 5 Pages 709-721
Kiyoko Kaneko, Yasuo Aoyagi, Tomoko Fukuuchi, Katsunori Inazawa, Noriko Yamaoka
Hematological Studies on Black Cumin Oil from the Seeds of Nigella sativa L.
March 29, 2002 | Volume 24 Issue 3 Pages 307-310
Shigeki ENOMOTO, Ryoya ASANO, Yoshihiro IWAHORI, Takao NARUI, Yoshihito OKADA, Abdel Nasser B. SINGAB, Toru OKUYAMA
Astragalus Extract Alleviates Nerve Injury after Cerebral Ischemia by Improving Energy Metabolism and Inhibiting Apoptosis
April 01, 2012 | Volume 35 Issue 4 Pages 449-454
Xiao-Ping Huang, Hua Tan, Bei-Yang Chen, Chang-Qing Deng
Effects of Ashwagandha (Roots of Withania somnifera) on Neurodegenerative Diseases
June 01, 2014 | Volume 37 Issue 6 Pages 892-897
Tomoharu Kuboyama, Chihiro Tohda, Katsuko Komatsu