Biological and Pharmaceutical Bulletin
The Pharmaceutical Society of Japan, established in 1880, is one of Japan’s oldest and most distinguished academic societies. The Society currently has around 15,000 members. It publishes three monthly scientific journals. Chemical and Pharmaceutical Bulletin (Chem. Pharm. Bull.) began publication in 1953 as Pharmaceutical Bulletin. It covers chemistry fields in the pharmaceutical and health sciences. Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics, which then merged the Journal of Health Science, another former Society’s journal, in 2012. It covers various biological topics in the pharmaceutical and health sciences. Yakugaku Zasshi (Japanese for “Pharmaceutical Science Journal”) has the longest history, with publication beginning in 1881. Yakugaku Zasshi is published mostly in Japanese, except for some articles related to clinical pharmacy and pharmaceutical education, which are published in English. The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, scientific communication, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.

Chairman of Committee
Hidehiko Nakagawa
Graduate School of Pharmaceutical Sciences, Nagoya City University
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11,655 registered articles
(updated on April 26, 2025)
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
1.7
2023 Journal Impact Factor (JIF)
JOURNAL PEER REVIEWED OPEN ACCESS FULL-TEXT HTML ADVANCE PUBLICATION
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Featured article
Volume 48 (2025) Issue 3 Pages 196-204
Molecular Epidemiological Features of Methicillin-Resistant Staphylococcus aureus in Japan Read more
Editor's pick

This review shows how the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in Japan has changed significantly in just a decade. In particular, the prevalence of the USA300 clone, a highly virulent community-associated MRSA, has become a serious problem in the community, and the number of patients with severe skin infections has increased. If such highly virulent strains of MRSA spread to hospitals, where there are many compromised patients, there is a risk of serious outbreaks. This review highlights the importance of staying abreast of the latest MRSA prevalence and implementing appropriate infection control.

Volume 48 (2025) Issue 3 Pages 205-212
Unique and Ingenious Mechanisms Underlying Antimicrobial Resistance and Spread of Haemophilus influenzae Read more
Editor's pick

Haemophilus influenzae is one of the most common pathogens causing community infections. Historically, H. influenzae has been known for its rapid emergence of antimicrobial-resistant isolates in response to antimicrobial usage. In this paper, the authors summarised the mechanisms of antimicrobial resistance to therapeutic agents based on recently published studies. Furthermore, they highlighted the transformation ability of H. influenzae, which allows it to adapt to its environment by acquiring extracellular DNA. This unique and ingenious feature could serve as an efficient system for the spread of antimicrobial resistance.

Volume 48 (2025) Issue 3 Pages 298-307
Evidence Showing Bombesin-Like Peptides Contract Guinea Pig Vas Deferens Smooth Muscle Read more
Editor's pick

[Highlighted Paper selected by Editor-in-Chief]
This study is the first to demonstrate that bombesin-like peptides—neuromedin B, gastrin-releasing peptide, and neuromedin C—induce contraction in guinea pig vas deferens smooth muscle (VDSM), likely through activation of bombesin BB2 receptors, highlighting a novel physiological role for these peptides. It further reveals that large-conductance Ca2+-activated K+ channels act as key negative regulators of VDSM contractility by suppressing voltage-dependent Ca2+ channels. These findings provide new insights into the regulation of the reproductive system and suggest potential therapeutic targets in urogenital physiology.

Volume 48 (2025) Issue 3 Pages 308-313
Development of a Digital Image-Based Method to Screen Molecules That Regulate Melanization Read more
Editor's pick

The authors established a simple method to quantify melanization by analyzing the digital images of the entire microplates. Compared to the conventional method measuring the absorbance of cell lysates at UV-A wavelengths, their digital image-based method was found to have higher sensitivity and be applicable to high-throughput screening assays to identify molecules that affect melanization.

Volume 48 (2025) Issue 3 Pages 323-335
Quetiapine Reverses the Behavior and Myelination in Alcohol-Exposed Gestational Diabetes Mellitus Offspring Mice via ERK1/2 Signaling Read more
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  • Biol. Pharm. Bull. Vol. 48 No. 3
    Current Topics: Recent Advances in Antibacterial Resistance by Japanese Pharmaceutical Scientists
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