INHIBITION OF SUPEROXIDE ANION PRODUCTION IN GUINEA PIG POLYMORPHONUCLEAR LEUKOCYTES BY A SELENO-OR-GANIC COMPOUND, EBSELEN

SHIGEMI ICHIKAWA; KAZUE OMURA; TERUAKI KATAYAMA; NAOKI OKAMURA; TOSHIAKI OHTSUKA; SADAHIKO ISHIBASHI; HIROYUKI MASAYASU

doi:10.1248/bpb1978.10.595

SHIGEMI ICHIKAWA, KAZUE OMURA, TERUAKI KATAYAMA, NAOKI OKAMURA, TOSHIAKI OHTSUKA, SADAHIKO ISHIBASHI, HIROYUKI MASAYASU

Author information

SHIGEMI ICHIKAWA
KAZUE OMURA
TERUAKI KATAYAMA
NAOKI OKAMURA
TOSHIAKI OHTSUKA
SADAHIKO ISHIBASHI
HIROYUKI MASAYASU
Author's Organization：
Department of Physiological Chemistry, Hiroshima University School of Medicine:Research Institute, Daiichi Seiyaku Co., Ltd.
Department of Physiological Chemistry, Hiroshima University School of Medicine:Research Institute, Daiichi Seiyaku Co., Ltd.
Department of Physiological Chemistry, Hiroshima University School of Medicine:Research Institute, Daiichi Seiyaku Co., Ltd.
Department of Physiological Chemistry, Hiroshima University School of Medicine:Research Institute, Daiichi Seiyaku Co., Ltd.
Department of Physiological Chemistry, Hiroshima University School of Medicine:Research Institute, Daiichi Seiyaku Co., Ltd.
Department of Physiological Chemistry, Hiroshima University School of Medicine:Research Institute, Daiichi Seiyaku Co., Ltd.
Department of Physiological Chemistry, Hiroshima University School of Medicine:Research Institute, Daiichi Seiyaku Co., Ltd.

Keywords: glutathione metabolism

JOURNAL FREE ACCESS

1987 Volume 10 Issue 10 Pages 595-597

DOI https://doi.org/10.1248/bpb1978.10.595

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Abstract

Production of superoxide anion (O^-₂) induced by tetradecanoyl phorbol acetate (TPA) in intact guinea pig polymorphonuclear leukocytes (PMNL) was markedly inhibited by a seleno-organic compound, 2-phenyl-1, 2-benzisoselenazol-3 (2H)-one (Ebselen), with glutathione peroxidase-like activity. The compound almost completely inhibited O^-₂ production by a particulate fraction prepared from TPA-treated PMNL at a concentration as low as 250 nM.

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