Journal of Pharmacobio-Dynamics
Online ISSN : 1881-1353
Print ISSN : 0386-846X
ISSN-L : 0386-846X
THE DIURETIC EFFECT OF FUROSEMIDE IN RELATION TO ITS DISPOSITION IN MAN
JIABI ZHUTAMOTSU KOIZUMI
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Keywords: furosemide
JOURNAL FREE ACCESS

1987 Volume 10 Issue 8 Pages 377-383

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Abstract
Experiments concerning the diuretic effect and disposition of furosemide were performed in nine healthy male volunteers. During the test period, each of subject was given 50 ml of water every half an hour. Under this experimental condition, interesting phenomena, such as almost identical duration of diuretic effect independent of given dose and the socalled clockwise hysteresis of the concentration-effect curve were observed. These phenomena revealed that the body water regulation system had intervened in the pharmacodynamics of furosemide. Based on experimental results, a model and a new equation are presented, which describe the quantitative relationship of the drug disposition, the diuretic response and the body water regulatory function.
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© The Pharmaceutical Society of Japan
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