1988 Volume 11 Issue 8 Pages 527-532
The effects of a highly branched β-1, 3-glucan, SSG, obtained from a culture filtrate of a fungus, Sclerotinia sclerotiorum IFO 9395, on the growth of syngeneic tumors and antitumor effector cells were examined. In the Meth A solid tumor systems, SSG administered intraperitoneally (i.p.), intralesionally (i.l.), or intravenously (i.v.) showed significant antitumor activities. Furthermore, SSG administered i.p. also showed effective activities against IMC carcinoma. SSG enhanced nonspecific antitumor effector functions, such as natural killer activity of spleen cells and the cytolytic activity of peritoneal macrophages. Additionally, SSG increased the specific immune response (cytotoxic T lymphocyte activity) against allogeneic tumor cells.
