INHIBITION OF [³H] GLUTAMATE RELEASE BY ZN²⁺ IN RAT HIPPOCAMPAL SLICES

Abstract

Zn²⁺ at the concentration of 10 μM inhibited the depolarization-induced [³H] glutamate release from the preloaded rat hippocampal slices both in the presence and absence of Ca²⁺ without affecting [³H] GABA and [³H] Ach release. Of divalent cations tested, Zn²⁺ and Fe<2+> had an inhibitory effect on the release of glutamate.