Journal of Pharmacobio-Dynamics
Online ISSN : 1881-1353
Print ISSN : 0386-846X
ISSN-L : 0386-846X
METHYLPREDNISOLONE REDUCES THE NEPHROTOXICITY CAUSED BY CISPLATIN
Jiro UOZUMIYasuhiro KOIKAWAToyofumi UEDA
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Keywords: nephrotoxicity
JOURNALS FREE ACCESS

1992 Volume 15 Issue 12 Pages 693-697

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Abstract

Male Sprague-Dawley rats were given either 6.5 or 8.5 mg/kg of iv cisplatin combined with three injections of sc methylprednisolone in doses of either 50, 100 or 250 mg/kg at -4, 0 and 4 h after the cisplatin injection. Blood urea nitrogen and serum creatinine levels were determined on day 5 following the cisplatin injection. The protective effects of methylprednisolone on cisplatininduced nephrotoxicity were clearly demonstrated. Our preliminary results suggest that a much higher dose of cisplatin could be injected in cancer chemotherapy, if it was combined with methylprednisolone.

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© The Pharmaceutical Society of Japan
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