Abstract
Colchicine, a microtubles-disrupting agent, when injected into subplantar region of the hind paw of rats, provoked an immediate elevation of the permeability of local vascular networks, resulting in a local tissue edema. The extent of the edema was dose-dependent. It was not affected at all by pretreatment of the rats with cyproheptadine, while cyproheptadine almost completely blocked formation of serotonin edema. When colchicine was applied together with serotonin, a synergistic enhancement of edema formation was observed. Colchicine and histamine were also synergistic.
