ENHANCEMENT OF LYMPHATIC TRANSPORT OF 1-(2-TETRAHYDROFURYL)-5-FLUOROURACIL BY WATER-IN-OIL EMULSION

YASUO NAKAMOTO; TOSHIYUKI TAKEEDA; FUMIYO SAKIKAWA; KAZUHIRO MORIMOTO; KATSUAKI MORISAKA; SHOZO MURANISHI; HITOSHI SEZAKI

doi:10.1248/bpb1978.2.45

Journal of Pharmacobio-Dynamics

Online ISSN : 1881-1353
Print ISSN : 0386-846X
ISSN-L : 0386-846X

ENHANCEMENT OF LYMPHATIC TRANSPORT OF 1-(2-TETRAHYDROFURYL)-5-FLUOROURACIL BY WATER-IN-OIL EMULSION

YASUO NAKAMOTO, TOSHIYUKI TAKEEDA, FUMIYO SAKIKAWA, KAZUHIRO MORIMOTO, KATSUAKI MORISAKA, SHOZO MURANISHI, HITOSHI SEZAKI

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Keywords: electron micrograph

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1979 Volume 2 Issue 1 Pages 45-51

DOI https://doi.org/10.1248/bpb1978.2.45

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Abstract

Enhancement of the lymphatic transport of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207), an orally active anticancer agent, was demonstrated by the administration of W/O emulsion into the loop of rat small intestine. The lymphatic transport of FT-207 was inhibited by the presence of bile. Absorption of oil in the absence of bile was confirmed by light microscopy. Electron micrograph revealed that oil droplets are mainly transported via the lymphatic system.

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