Abstract
An allergic footpad inflammation of mice was induced by using azobenzenearsonateacetyl bovine serum albumin conjugate as an antigen. Sensitization was made with the aid of Freund's complete adjuvant and the allergic reaction was elicited by using an emulsion consisting of Freund's incomplete adjuvant and 0.9% NaCl solution as a carrier of the challenging antigen. Allergic footpad swelling reached a maximum 24 hr after the challenge dose. D-Penicillamine, an anti-rheumatic drug, exerted a strong inhibitory effect on the allergic process, if animals were treated with this drug for 21 days at a dose of 600 mg/kg/day.
