A radioimmunoassay has been developed which enables accurate determination of haloperidol in human serum. Antiserum was prepared by immunizing guinea pigs with haloperidol (O-carboxymethyl) oxime derivative (III) coupled with bovine serum albumin. With the antiserum, 3H-haloperidol and dextran-coated charcoal, the assay of haloperidol in serum was possible over a concentration range of 1 to 50 ng/ml, using 0.1 ml of human serum without the need of an extraction procedure. Data obtained by radioimmunoassay are in good agreement with those obtained by gas chromatography. No appreciable cross-reactivity was observed neither with haloperidol metabolites nor with other butyrophenone neuroleptics. Serum levels of haloperidol in schizophrenic patients receiving single oral dosing (6 mg/subject) have also been determined.
- Correlation of Left Ventricular Pressure Changes and Left Atrial Function on Strain Rate Imaging During Acute Left Ventricular Ischemia
- Effects of Diltiazem and Nitroglycerin on Left Ventricular Diastolic Properties in Patients with Coronary Artery Disease
- Hemodynamic Effect of Bunitrolol on Patients with Ischemic Heart Disease
- EFFECTS OF VITAMIN E DEPLETION AND REPLETION ON RENIN RELEASE FROM RENIN GRANULES
- EFFECT OF VITAMIN E-DEFICIENCY ON RENIN RELEASE FROM RENIN GRANULES