CHARACTERISTIC BIOTRANSFORMATION OF AMINOPYRINE IN RAT WHEN ADMINISTERED WITH BARBITAL

KENJI MATSUYAMA; KAZUTAKE KADO; MASANORI NISHIUCHI; TSUYOSHI GOROMARU; OSAMI TSUZUKI; ATSUKO NODA; SADAO IGUCHI

doi:10.1248/bpb1978.4.28

KENJI MATSUYAMA, KAZUTAKE KADO, MASANORI NISHIUCHI, TSUYOSHI GOROMARU, OSAMI TSUZUKI, ATSUKO NODA, SADAO IGUCHI

Author information

Keywords: GC-MS analyses

JOURNAL FREE ACCESS

1981 Volume 4 Issue 1 Pages 28-34

DOI https://doi.org/10.1248/bpb1978.4.28

Details

Abstract

After the administration of aminopyrine with or without barbital to rats, aminopyrine and its main metabolites were detected in plasma and the brain by means of gas chromatography-mass spectrometry. It was clarified that a marked increase of 4-monomethylaminoantipyrine was observed in the case of coadministration of aminopyrine and barbital, while the plasma level of aminopyrine decreased significantly compared with single administration.

Corresponding author

Register with J-STAGE for free!