Journal of Pharmacobio-Dynamics
Online ISSN : 1881-1353
Print ISSN : 0386-846X
ISSN-L : 0386-846X
A PHARMACOKINETIC ANALYSIS PROGRAM (MULTI) FOR MICROCOMPUTER
KIYOSHI YAMAOKAYUSUKE TANIGAWARATERUMICHI NAKAGAWATOYOZO UNO
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Keywords: least squares
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1981 Volume 4 Issue 11 Pages 879-885

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Abstract

A nonlinear least squares program (MULTI) for microcomputers was developed. The program is written in BASIC programming language. Four algorithms, (1) Gauss-Newton method, (2) damping Gauss-Newton method, (3) modified Marquardt method and (4) simplex method, can be used for nonlinear curve fitting in MULTI. Up to five pharmacokinetic equations, which are voluntarily defined by the user, are simultaneously fitted to observed time courses. The executions of MULTI are demonstrated for time courses of ampicillin and oxacillin in man.

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