Author's Organization：Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
In in situ experiments on spinal rats transected at the C1 level and on non-spinal rats, muscimol (3 mg/kg, i.v.) depolarized the primary afferent fibers and diazepam (3 mg/kg, i.v.) potentiated this effect of muscimol. When diazepam was given for 14 days, the effect of muscimol was significantly reduced in non-spinal, but not in spinal rats. These findings suggest that diazepam probably interacts with GABA-ergic mechanisms more closely in supraspinal regions of the rat.
