Author's Organization：Faculty of Pharmaceutical Sciences, Kyushu University:(Present address)Faculty of Pharmaceutical Sciences, Fukuoka University / Faculty of Pharmaceutical Sciences, Kyushu University
In addition to six metabolites of oxycodone which were reported previously, 7β-hydroxy-6β-oxycodol was further isolated as one of the major metabolites in rabbits. The structure of this novel metabolite was characterized by mass and nuclear magnetic resonance spectra. Such a metabolite possessing vicinal hydroxyl groups in aliphatic ring is very new in the metabolism of narcotic analgesics.
