EFFECTS ON GASTRIC ACID SECRETION OF A STEROIDAL ALKALOID, EPIPACHYSAMINE-A, EXTRACTED FROM PACHYSANDRA TERMINALIS SIEB.ET ZUCC

Abstract

Effect of a steroidal alkaloid, epipachysamine-A, extracted from Pachysandra terminalis SIEB. et ZUCC. on gastric acid secretion was studied in rats. Epipachysamine-A prevented 2-deoxy-D-glucose-or thyrotropin-releasing hormone-stimulated gastric acid secretion in anesthetized rats. However, the compound did not influence bethanechol-or electrical vagal stimulation-induced gastric acid secretion. These results suggest that the effect of epipachysamine-A is due to the influence on the central nervous regulatory mechanism in the gastric acid secretion.