Abstract
Intraperitoneal administration of neurotropin (NSP) did not modify the antibody response to sheep red blood cells (SRBC) in normal BALB/c mice. However, the suppressed antibody responses to SRBC in restraint-stressed mice were favorably restored to normal level by NSP at a dose of 10 or 25 mg/kg either before or even after the stress loading. The suppressed antibody responses in hydrocortisone-treated mice were restored by NSP when it was administered after cortisone. Moreover, NSP augmented the in vitro antibody response to a T cell-dependent antigen, SRBC, but not to T cell-independent antigens such as dinitrophenylated-Ficoll and trinitrophenylated-lipopolysaccharide.
