Abstract
Prolonged immobilization, as in the cases of bed rest or astronauts flying in space, is known to result in less activity and keeping skeletal muscle under unstretched condition. This inactivity will seriously threaten the quality of life not only of the Aged also every persons in modern society. There were a lot of researches on dynamicity of structure and function of muscle fiber under micro-gravity and hyper-gravity, while less about ECM. We have examined changes of the amount of molecular chaperone HSP47 as well as collagens. We have found rapid changes of HSP47 associating with collagens at 30 min after transition of gravity. New corresponding regulation of gravity-relating gene expression will be uncovered soon.
